Investigation of Biochemical Markers of Covid-19 Infected Patients

Identify Biomarkers of Covid-19 Positive Patients

Abstract

Covid-19 is a highly contagious viral disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-COV-2). The objective of this research was to assess the clinical and hematological parameters of COVID-19-positive patients in order to identify potential biomarkers for the disease. The study included 2661 clinical reports from patients aged 25-90, with 1588 males and 1073 females. Blood samples were analyzed for various parameters and the N gene was targeted for SARS-CoV-2 detection through PCR. Statistical analysis was performed using SPSS 22.0 and presented results with mean values and standard deviations, with significance levels set at P < 0.05. Our study found that 59.7% of patients were male and within the 41-65 age group. Hematological analysis revealed significant associations between RBC levels (P < 0.001*) and normal monocyte levels (P = 0.04*). Additionally, 87% of patients had lymphopenia, 78% had leukocytosis, 84.6% had neutrophilia and 11.3% had thrombocytopenia. Clinical profiles showed elevated levels of CRP (98.9%), LDH (74.2%), ferritin (84.8%), D-dimer (97.8%) and significant association with albumin (<0.01). Finally, variations in urea and creatinine suggested potential renal involvement.