Synthesis and Characterization of Homo and Mixed Ligand Complexes of Fe(III) with Hydroxypyridinone and Hydroxypyranone Type Ligands

Kanwal Zahid; Shazia Nisar; Saima Imad; Shazia Perveen; Shazia Ghaffar; Nasreen Fatima

doi:10.52763/PJSIR.PHYS.SCI.63.1.2020.12.17

Kanwal Zahid Department of Chemistry, University of Karachi, Karachi-75270, Pakistan
Shazia Nisar Department of Chemistry, University of Karachi, Karachi-75270, Pakistan
Saima Imad Chemical Metrology Division, National Physical and Standards Laboratory (PCSIR), Islamabad, Pakistan
Shazia Perveen Department of Chemistry, NED University of Engineering and Technology, Karachi-75270, Pakistan
Shazia Ghaffar Department of Chemistry, University of Karachi, Karachi-75270, Pakistan
Nasreen Fatima Department of Chemistry, University of Karachi, Karachi-75270, Pakistan

DOI: https://doi.org/10.52763/PJSIR.PHYS.SCI.63.1.2020.12.17

Keywords: mixed ligand complexes, iron, hydroxypyridinone, hydroxypyranone, chelation therapy

Abstract

Hydroxypyridinone and hydroxypyranone are known to be used for the treatment of iron overload by chelation therapy for a long time. Both the ligands have their own side effects when used as medicines. In the present study homo and mixed ligand complexes of both the ligands with iron were prepared and characterized by UV-visible spectrophotometry, Potentiometric study, IR spectroscopy, SEM/EDX and XRD. Overlay spectra obtained from UV-visible spectroscopy of our studied system show the formation of different types of species and confirm that mixed ligand complex is different from the other two systems. Potentiometric titration curves of homo and mixed ligand complexes show the formation of different types of species at different pH and confirm the formation of mixed ligand complex. The comparative results of SEM images of these systems show different surface topologies and hence conform to the formation of mixed ligand complex.