Identification of Medicinal Organic Components of  Andrographis paniculata Leaf Extracts

Mudiaga Chukunedum Onojake; Raphael I. Ngochindo; Beatrice Ihuoma Okocha

doi:10.52763/PJSIR.PHYS.SCI.63.1.2020.48.54

Mudiaga Chukunedum Onojake Centre for Marine Pollution Monitoring and Seafood Safety, University of Port Harcourt, PMB-5323,Choba, Port Harcourt, Nigeria
Raphael I. Ngochindo Department of Pure and Industrial Chemistry, University of Port Harcourt, PMB-5323, Choba, Port Harcourt, Nigeria
Beatrice Ihuoma Okocha Department of Pure and Industrial Chemistry, University of Port Harcourt, PMB-5323, Choba, Port Harcourt, Nigeria

DOI: https://doi.org/10.52763/PJSIR.PHYS.SCI.63.1.2020.48.54

Keywords: andrographolide, ethanol extract, therapy, antimalarial, chromatography, Andographis paniculata leaf

Abstract

Active metabolites of methanol, ethanol, ethyl acetate and aqueous extracts of the leaves of Andrographis paniculata were identified using thin layer chromatography and gas chromatography-mass spectrometry (GC-MS). Results from this study identified some of active metabolites as andrographolide, 14-deoxyandrographolide, neoandrographolide, 14-deoxy-11,12-di-dehydroandrographolide, andrographanin, isoandrographolide, 14-acetylandrographolide, 19-0-andrographolide, beta-sitosterol and 14-deoxy-14,15- dihydroandrographolide. Ethanol was a more effective solvent for the extraction as most of the phytochemicals were identified in this extract. Research had shown that extracts from the leaves of the plant possess a lot of therapeutic properties such as anti-microbial, anti-inflammatory, anti-diabetic, immune modulatory and antimalarial activities which are of immense benefit to man.