Synthesis, Characterization and Antimicrobial Activity of Thiol Substituted Triazole Amic Acids
Synthesis of Triazole Amic Acids
Triazole-based compounds exhibit varying pharmacological properties in the treatment of fungal, bacterial and other significant infectious diseases. This study presents the synthesis and characterization of a series of thiol-substituted 1,2,4-triazole amic acids as potential antimicrobial agents. The amic acid compounds were synthesized by condensing 1,2,4- triazole-5-thiol with phthalic anhydride, 3-nitrophthalic anhydride, succinic anhydride and 3,3'4,4'-tetracarboxylic dianhydride. The structures of the thiol-substituted triazole amic acids have been elucidated with CHNS, conductivity, infrared and nuclear magnetic resonance spectral data. The compounds were tested for their antimicrobial susceptibility using four bacterial strains and one fungal strain, namely: Staphylococcus aureus, Streptococcus faecalis, Escherichia coli, Salmonella paratyphimurium and Candida albicans. The amic acid compounds are non- electrolyte (AM = 9.72 - 17.690.-1 cm2/mol). The relevant IR bands, 1H- and 13C- NMR spectral data suggest that the proposed thiol-substituted amic acids were formed, while the electronic spectra reveal exhibit n � n* absorption bands at 280 - 315 nm. All the synthesized amic acids exhibited mild anti-bacterial antifungal activity against the tested organisms.