The Anti-depressant Activity of Fixed Oil of Phaseolus vulgaris Linn. in Mice

Salma Sabir; Sadia Ghousia Baig; Muhammad Mohtasheem ul Hasan Mohtasheem ul Hasan; Afshan Siddiq; Salman Ahmed; Syeda Anum Fatima

doi:10.52763/PJSIR.PHYS.SCI.64.1.2021.1.5

Salma Sabir Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan
Sadia Ghousia Baig Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan
Muhammad Mohtasheem ul Hasan Mohtasheem ul Hasan Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan
Afshan Siddiq Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan
Salman Ahmed Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan
Syeda Anum Fatima Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan

DOI: https://doi.org/10.52763/PJSIR.PHYS.SCI.64.1.2021.1.5

Keywords: Phaseolus vulgaris, fixed oil, anti-depressant, forced swim test, tail suspension test, beans

Abstract

Phaseolus vulgaris Linn commonly known as red kidney bean, it is enriched in protein, carbohydrates and dietary fibres. Beans have nutritional and health benefits and also possess antimicrobial, antihyperglycemic, antioxidant and anticancer activity due to presence of bio-active chemical constituents. The following study was carried out to evaluate the anti-depressant activity of Phaseolus vulgaris fixed oil (PVFO) using forced swim test and tail suspension test in mice. In this study animals assigned into four groups (n=7). Group I: Control normal saline (2 mL/Kg), Group II: PVFO I (2 mL/Kg), Group III: PVFO II (4 mL/Kg) and Group IV: standard amitriptyline (10 mg/Kg). The results were significant and indicated the possible anti-depressant role of Phaseolus vulgaris fixed oil.