Review Nanocarriers for the Oral Delivery of Drugs With Special Focus on Porous Silicon: A Review
Review: Nanocarriers for the Oral Delivery of Drugs
The focus concerning controlled drug release requires the growth of appropriate drug carriers that could move adequate amount of the drug to injured area with controlled and sustained manner. A variety of nanoparticles including magnetic nanoparticles, the staes, liposomes, polymers dendrimers, solid lipid nanoparticles (SLN) and porous silicon have been investigated as drug carriers in drug delivery cases. Nanocarriers have achieved significant importance in the stabilization of proteins and peptides, anti-cancer drug camptothecin (CPT) and bone tissue engineering offering improved buccal access and protection according to the desired function. Moreover, tailored formulation along with functionalization and bio- compatibility has importance in fabrication of nanoparticles for proteins or peptides via oral delivery systems, which has advantage over parenteric delivery systems because of their comfort running and observance to treatment. The review summarizes interesting approaches on existing publications for drugs such as proteins or peptides carrier nanoparticles with special focus on porous silicon for delivery systems. Fabricatioan of nanoparticles e.g. porous silicon nanocarriers for oral delivery, advantages and disadvantages, prospective use of porous silicon in drug delivery systems will be addressed.