The Protective and Curative Role of Methanolic Extract of Pistacia integerrima Stew Ex-brandis Galls in Nimesulide Induced Hepatorenal Intoxication in Rabbits

Role of Pistacia integerrima Stew in Rabbits

Abstract

We investigated the defensive and curative role of methanolic extract of Pistacia integerrima (PI) galls in Nimesulide induced hepatorenal intoxication in rabbits. Extracts of PI galls were administered orally at 100, 300 and 500 mg/Kg/day along with Nimesulide (5 mg/Kg/day), while the same doses of extracts were administered in healing phase (pre-intoxication with Nimesulide). Nimesulide resulted in a remarkable elevation of hepato-specific enzymes (P<0.05) and mild increase (P<0.05) in the renal biomarkers, as compared to normal. All the investigated doses of the methanolic extract of PI galls showed more pronounced hepato-protection (P<0.05) than standard (Silymarin at 50 mg/Kg/day). Extract of PI galls administered at 300 mg/Kg/day revealed the same reno-protective response (P>0.05) as observed in the standard (vitamin-C at 40 mg/Kg/day) and showed better response (P<0.05) in renal protection than other two doses of extracts. This study showed that methanolic extract of PI galls have significant protective and curative role in the hepatorenal toxicity induced by Nimesulide.